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Viruses such as SARS-CoV-2 and influenza A shift host energy metabolism toward glycolysis while reducing OXPHOS, ensuring rapid biomass production favorable for replication (Shin et al., 2024)

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In contrast, in the GSTP-silenced state on Day 2 of siRNA infection, depolarized mitochondria formed a network-like structure or aggregate distribution, and polarized functional mitochondria were significantly reduced (Fig